Potential Combinations of Pasak Bumi (Eurycoma longifolia Jack), Docosahexaenoic Acid, and Seluang Fish (Rasbora spp.) to Improving Oxidative Stress of Rats (Rattus norvegicus) Brain Undernutrition

BACKGROUND: The brain is very susceptible to damage from oxidative stress due undernutrition. Provision of nutrients and compounds that act as antioxidants needed improve in the brain. AIM: This study was conducted with aim proving potential combination pasak bumi (Eurycoma longifolia Jack), DHA, seluang fish (Rasbora Spp.) brains undernourished rats (Rattus norvegicus). METHODS: Once were undernourished, they divided: positive control (KP) = + placebo standard feed; (P1) 70% ethanol extract root (EPB) 15 mg/kg BW (P2) DHA 1 mg/kgBW (P3) EPB (P4) fish; (P5) for 5 weeks; plus negative group (KN) healthy given feed. parameters included superoxide dismutase (SOD) activity, catalase, peroxide (H2O2) malondialdehyde (MDA) levels. Data analysis used Kruskall-Wallis test followed by Mann Whitney a significance level 95%. RESULTS: There significant differences activity SOD (p 0.001), catalase 0.000), levels MDA 0.000) between treatments. showed better lower than other groups. CONCLUSION: has best compared single administration EPB, or alone.